New Drug R&D

Almotriptan Malate Tablets

Product Name: Almotriptan Malate Tablets
Dosage Forms: Tablet
Strengths: 6.25 mg, 12.5 mg
Mechanism of Action:
Almotriptan binds with high affinity to 5-HT1D, 5-HT1B, and 5-HT1F receptors. Almotriptan has weak affinity for 5-HT1A and 5-HT7 receptors, but has no significant affinity or pharmacological activity at 5-HT2, 5-HT3, 5-HT4, 5-HT6; alpha or beta adrenergic; adenosine (A1, A2); angiotensin (AT1, AT2); dopamine (D1, D2); endothelin (ETA, ETB); or tachykinin (NK1, NK2, NK3) binding sites.
It is indicated for:
•  Acute treatment of migraine attacks in adults with a history of migraine with or without aura.
•  Acute treatment of migraine headache pain in adolescents age 12 to 17 years with a history of migraine with or without aura, and who have migraine attacks usually lasting 4 hours or more.
Status: Has received the acceptance notification in April, 2014.
Processing Number: CXHL1400480, CXHL1400481, CXHL1400482

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